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Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic

  1. Author:
    Savid-Frontera, Constanza [ORCID]
    Viano, Maria E [ORCID]
    Baez, Natalia S [ORCID]
    Reynolds, Della
    Matellon, Mariana
    Young,Howard [ORCID]
    Rodriguez-Galan, Maria C [ORCID]

  2. Author Address

    Inmunolog 237;a, CIBICI-CONICET, Facultad de Ciencias Qu 237;micas, Universidad Nacional de C 243;rdoba, C 243;rdoba, 5000, Argentina., Cancer & Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201 USA.,
    1. Year: 2021
    2. Date: Nov 16
    3. Epub Date: 2021 Nov 16
  2. Journal: Immunotherapy
  4. Type of Article: Article
  5. ISSN: 1750-743X
  1. Abstract:

    Aim: The aim of this work is to utilize a gene expression procedure to safely express systemic IL-12 and evaluate its effects in mouse tumor models. Materials & methods: Secondary lymphoid organs and tumors from EL4 and B16 tumor-bearing mice were analyzed by supervised and unsupervised methods. Results: IL-12 cDNA induced systemic IL-12 protein levels lower than the tolerated dose in patients. Control of tumor growth was observed in subcutaneous B16 and EL4 tumors. Systemic IL-12 expression induced a higher frequency of both total tumor-infiltrated CD45+ cells and proliferative IFN-?+CD8+ 160;T cells along with a lower frequency of CD4+FOXP3+ and CD11b+Gr-1+ cells. Conclusion: This approach characterizes the systemic effects of IL-12, helping to improve 160;treatment of metastases or solid tumors.

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External Sources

  1. View Full Text
  2. DOI: 10.2217/imt-2021-0080
  3. PMID: 34783257
  4. View record in Web of Science®
  5. WOS: 000718900100001

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