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Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis

  1. Author:
    Phang,James [ORCID]

  2. Author Address

    Scientist Emeritus, Mouse Cancer Genetics Program, CCR, NCI at Frederick, National Institutes of Health, Frederick, MD, 21702, USA.,
    1. Year: 2021
    2. Date: Nov 26
    3. Epub Date: 2021 11 26
  2. Journal: Amino acids
  4. Type of Article: Article
  5. ISSN: 0939-4451
  1. Abstract:

    In the 35 years since the introduction of the "proline cycle", its relevance to human tumors has been widely established. These connections are based on a variety of mechanisms discovered by many laboratories and have stimulated the search for small molecule inhibitors to treat cancer or metastases. In addition, the multi-layered connections of the proline cycle and the role of proline and hydroxyproline in collagen provide an important regulatory link between the extracellular matrix and metabolism. © 2021. The Author(s).

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External Sources

  1. View Full Text
  2. DOI: 10.1007/s00726-021-03103-7
  3. PMID: 34825974
  4. View record in Web of Science®
  5. WOS: 000722828000001
  6. PII : 10.1007/s00726-021-03103-7

Library Notes

  1. Fiscal Year: FY2021-2022
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