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Inhibition of Tumor Promoter Induced Transformation By Expression of the Small Gtp-Binding Protein Rac in Jb6 Cells

  1. Author:
    Dong, Z. G.
    Ding, M.
    Ma, W. Y.
    Colburn, N. H.

  2. Author Address

    Dong ZG UNIV MINNESOTA HORMEL INST 801 16TH AVE NE AUSTIN, MN 55912 USA US FDA HEPATATIS LAB DTTD BETHESDA, MD 20892 USA NCI FREDERICK CANC RES & DEV CTR GENE REGULAT SECT LAB BIOCHEM PHYSIOL FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: International Journal of Oncology
    1. 11
    2. 1
    3. Pages: 157-161
  4. Type of Article: Article
  1. Abstract:

    The small GTP-binding protein rac-1 has been reported to be a mediator for tumor promoter, growth factor and serum-induced cell membrane ruffling. We have stably overexpressed rac-1 in JB6 P+ cells. In contrast to rac-1 expressing NIH/3T3 cells, all JB6 transfectants expressing rac-1 did not show tumorigenic transformation (forward progression) but instead showed anti-oncogenic effects (backward progression). Transfectants expressing high levels of rac-1 were blocked for TPA-, EGF- and serum-induced transformation, while transfectants expressing lower levels of rac-1 were completely blocked for EGF- and serum-induced transformation but only partially inhibited for TPA-induced transformation compared with vector control transfectants. [References: 39]

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