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LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells

  1. Author:
    Yang, D.
    Chen, Q.
    Schmidt, A. P.
    Anderson, G. M.
    Wang, J. M.
    Wooters, J.
    Oppenheim, J. J.
    Chertov, O.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, IRSP, SAIC, NIH, Bldg 560, Rm 31-19, Frederick, MD 21701 USA. NCI, Frederick Canc Res & Dev Ctr, IRSP, SAIC, NIH, Frederick, MD 21701 USA. Sci Applicat Int Corp, Div Basic Sci, Mol Immunoregulat Lab, Frederick, MD USA. Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD USA. Magainin Pharmaceut Inc, Plymouth Meeting, PA 19462 USA. Genet Inst, Cambridge, MA 02140 USA.
    1. Year: 2000
  2. Journal: Journal of Experimental Medicine
    1. 192
    2. 7
    3. Pages: 1069-1074
  4. Type of Article: Article
  1. Abstract:

    We have previously shown that antimicrobial peptides like defensins have the capacity to mobilize leukocytes in host defense. LL-37 is the cleaved antimicrobial 37-residue, COOH- terminal peptide of hCAP18 (human cationic antimicrobial protein with a molecular size of 18 kD), the only identified member in humans of a family of proteins called cathelicidins. LL-37/hCAP18 is produced by neutrophils and various epithelial cells. Here we report that LL-37 is chemotactic for, and can induce Ca2+ mobilization in, human monocytes and formyl peptide receptor-like 1 (FPRL1)-transfected human embryonic kidney 293 cells. LL-37-induced Ca2+ mobilization in monocytes can also be cross-desensitized by an FPRL1-specific agonist. Furthermore, LL-37 is also chemotactic for human neutrophils and T lymphocytes that are known to express FPRL1. Our results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.

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