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Quality of life of HIV-negative, previously healthy individuals following cryptococcal meningoencephalitis

  1. Author:
    Dean, Owen
    Anjum, Seher
    Scott, Terri
    Ham, Lillian
    Traino, Katherine
    Wang,Jing
    Hunsberger, Sally
    Powers,John
    Marr, Kieren A.
    Snow, Joseph
    Williamson, Peter R.

  2. Author Address

    NIAID, Lab Clin Immunol & Microbiol, NIH, Bld 10,Rm 11C208,9000 Rockville Pike, Bethesda, MD 20892 USA.NIMH, NIH, Bethesda, MD 20892 USA.NIAID, Biostat Res Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Frederick Natl Lab Canc Res, Clin Res Directorate, Frederick, MD USA.Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
    1. Year: 2021
    2. Date: Feb 11
  2. Journal: Scientific Reports
  3. Nature Research
    1. 11
    2. 1
  5. Type of Article: Article
  6. Article Number: ARTN 3673
  7. ISSN: 2045-2322
  1. Abstract:

    The morbidity and mortality of cryptococcal meningoencephalitis (CM) in previously healthy, HIV-negative individuals is increasingly recognized. We administered a healthcare associated quality of life (QOL) survey to the largest longitudinally followed cohort of these patients in the United States. We identified moderate or severe self-reported impairment in at least one QOL domain in 61% of subjects at least one year following diagnosis. Self-reported cognitive impairment was noted in 52% and sleep disturbance was noted in 55%. This is the first comprehensive study of cross-sectional long-term QOL in previously healthy patients following cryptococcal infection.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41598-021-83176-2
  3. PMID: 33574462
  4. PMCID: PMC7878796
  5. View record in Web of Science®
  6. WOS: 000626726100046

Library Notes

  1. Fiscal Year: FY2020-2021
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