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Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia

  1. Author:
    Blechter, Batel
    Wong, Jason Y. Y.
    Hsiung, Chao Agnes
    Hosgood, H. Dean
    Yin, Zhihua
    Shu, Xiao-Ou
    Zhang, Han
    Shi, Jianxin
    Song, Lei
    Song, Minsun
    Zheng, Wei
    Wang, Zhaoming
    Caporaso, Neil
    Burdette, Laurie
    Yeager, Meredith
    Berndt, Sonja I.
    Landi, Maria Teresa
    Chen, Chien-Jen
    Chang, Gee-Chen
    Hsiao, Chin-Fu
    Tsai, Ying-Huang
    Chen, Kuan-Yu
    Huang, Ming-Shyan
    Su, Wu-Chou
    Chen, Yuh-Min
    Chien, Li-Hsin
    Chen, Chung-Hsing
    Yang, Tsung-Ying
    Wang, Chih-Liang
    Hung, Jen-Yu
    Lin, Chien-Chung
    Perng, Reury-Perng
    Chen, Chih-Yi
    Chen, Kun-Chieh
    Li, Yao-Jen
    Yu, Chong-Jen
    Chen, Yi-Song
    Chen, Ying-Hsiang
    Tsai, Fang-Yu
    Seow, Wei Jie
    Bassig, Bryan A.
    Hu, Wei
    Ji, Bu-Tian
    Wu, Wei
    Guan, Peng
    He, Qincheng
    Gao, Yu-Tang
    Cai, Qiuyin
    Chow, Wong-Ho
    Xiang, Yong-Bing
    Lin, Dongxin
    Wu, Chen
    Wu, Yi-Long
    Shin, Min-Ho
    Hong, Yun-Chul
    Matsuo, Keitaro
    Chen, Kexin
    Wong, Maria Pik
    Lu, Daru
    Jin, Li
    Wang, Jiu-Cun
    Seow, Adeline
    Wu, Tangchun
    Shen, Hongbing
    Fraumeni, Joseph F.
    Yang, Pan-Chyr
    Chang, I-Shou
    Zhou, Baosen
    Chanock, Stephen J.
    Rothman, Nathaniel
    Chatterjee, Nilanjan
    Lan, Qing

  2. Author Address

    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St, Baltimore, MD 21202 USA.NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang, Peoples R China.Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.Vanderbilt Ingram Canc Ctr, Nashville, TN USA.Sookmyung Womens Univ, Dept Stat, Seoul, South Korea.St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA.Frederick Natl Lab Canc Res, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Frederick, MD USA.Leidos Biomed Res Inc, Frederick, MD USA.Acad Sinica, Genom Res Ctr, Taipei, Taiwan.Natl Yang Ming Univ, Sch Med, Fac Med, Taipei, Taiwan.Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Taichung, Taiwan.Chiayi Chang Gung Mem Hosp, Div Pulm & Crit Care Med, Chiayi, Taiwan.Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.I Shou Univ, Sch Med, E Da Canc Hosp, Dept Internal Med, Kaohsiung, Taiwan.Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Internal Med, Coll Med, Tainan, Taiwan.Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan.Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan.Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan.Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Sch Med, Dept Internal Med, Kaohsiung, Taiwan.Chung Shan Med Univ, Inst Med, Taichung, Taiwan.Chung Shan Med Univ Hosp, Div Thorac Surg, Dept Surg, Taichung, Taiwan.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China.Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA.Chinese Acad Med Sci & Peking Union Med Coll, Dept Etiol & Carcinogenesis, Canc Inst & Hosp, Beijing, Peoples R China.Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Mol Oncol, Canc Inst & Hosp, Beijing, Peoples R China.Guangdong Acad Med Sci, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Peoples R China.Guangdong Acad Med Sci, Canc Ctr Guangdong Gen Hosp, Guangzhou, Peoples R China.Chonnam Natl Univ, Dept Prevent Med, Med Sch, Gwangju, South Korea.Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea.Aichi Canc Ctr Res Inst, Div Mol Med, Nagoya, Aichi, Japan.Tianjin Med Univ Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin, Peoples R China.Univ Hong Kong, LKS Fac Med, Dept Pathol, Hong Kong, Peoples R China.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China.Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth Sch Publ Hlth, Wuhan, Peoples R China.Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Sch Publ Hlth, Wuhan, Peoples R China.Nanjing Med Univ, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Collaborat Innovat Ctr Canc Personalized Med, Dept Epidemiol & Biostat,Sch Publ Hlth, Nanjing, Peoples R China.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA.
    1. Year: 2021
    2. Date: Feb
    3. Epub Date: 2020 Dec 29
  2. Journal: Environment International
  3. Pergamon-Elsevier Science Ltd
    1. 147
  5. Type of Article: Article
  6. Article Number: ARTN 105975
  7. ISSN: 0160-4120
  1. Abstract:

    We previously identified 10 lung adenocarcinoma susceptibility loci in a genome-wide association study (GWAS) conducted in the Female Lung Cancer Consortium in Asia (FLCCA), the largest genomic study of lung cancer among never-smoking women to date. Furthermore, household coal use for cooking and heating has been linked to lung cancer in Asia, especially in Xuanwei, China. We investigated the potential interaction between genetic susceptibility and coal use in FLCCA. We analyzed GWAS-data from Taiwan, Shanghai, and Shenyang (1472 cases; 1497 controls), as well as a separate study conducted in Xuanwei (152 cases; 522 controls) for additional analyses. We summarized genetic susceptibility using a polygenic risk score (PRS), which was the weighted sum of the risk-alleles from the 10 previously identified loci. We estimated associations between a PRS, coal use (ever/never), and lung adenocarcinoma with multivariable logistic regression models, and evaluated potential gene-environment interactions using likelihood ratio tests. There was a strong association between continuous PRS and lung adenocarcinoma among never coal users (Odds Ratio (OR) = 1.69 (95% Confidence Interval (CI) = 1.53, 1.87), p=1 x 10(-26)). This effect was attenuated among ever coal users (OR = 1.24 (95% CI: 1.03, 1.50), p = 0.02, p-interaction = 6 x 10(-3)). We observed similar attenuation among coal users from Xuanwei. Our study provides evidence that genetic susceptibility to lung adenocarcinoma among never-smoking Asian women is weaker among coal users. These results suggest that lung cancer pathogenesis may differ, at least partially, depending on exposure to coal combustion products. Notably, these novel findings are among the few instances of sub-multiplicative gene-environment interactions in the cancer literature.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.envint.2020.105975
  3. PMID: 33385923
  4. PMCID: PMC8378844
  5. View record in Web of Science®
  6. WOS: 000614535400002

Library Notes

  1. Open Access Publication
  2. Fiscal Year: FY2020-2021
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