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Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

  1. Author:
    Avila, Yelixza I.
    Chandler, Morgan
    Cedrone,Edward
    Newton,Hannah
    Richardson, Melina
    Xu,Jie
    Clogston,Jeffrey
    Liptrott, Neill J.
    Afonin, Kirill A.
    Dobrovolskaia,Marina

  2. Author Address

    Univ North Carolina Charlotte, Dept Chem, Nanoscale Sci Program, Charlotte, NC 28223 USA.NCI, Nanotechnol Characterizat Lab, Canc Res Technol Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Pharmacol & Therapeut, Liverpool L7 3NY, Merseyside, England.
    1. Year: 2021
    2. Date: Feb
  2. Journal: Molecules
  3. MDPI,
    1. 26
    2. 3
  5. Type of Article: Article
  6. Article Number: ARTN 652
  7. ISSN: 1420-3049
  1. Abstract:

    Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules26030652
  3. PMID: 33513786
  4. PMCID: PMC7865455
  5. View record in Web of Science®
  6. WOS: 000615432600001

Library Notes

  1. Fiscal Year: FY2020-2021
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