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2'-Fluoro-2',3'-Dideoxyarabinosyladenine (F-Dda) - Activity Against Drug-Resistant Human Immunodeficiency Virus Strains and Clades a-E

  1. Author:
    Driscoll, J. S.
    Mayers, D. L.
    Bader, J. P.
    Weislow, O. S.
    Johns, D. G.
    Buckheit, R. W.

  2. Author Address

    Driscoll JS NCI MED CHEM LAB DIV BASIC SCI NIH BLDG 37 ROOM 5C-02 BETHESDA, MD 20892 USA WALTER REED ARMY INST RES ROCKVILLE, MD 20850 USA NCI ANTIVIRAL EVALUAT BRANCH ROCKVILLE, MD 20852 USA SRA TECHNOL ROCKVILLE, MD 20850 USA FREDERICK CANC RES & DEV CTR SO RES INST VIROL RES GRP FREDERICK, MD 21701 USA
    1. Year: 1997
  2. Journal: Antiviral Chemistry & Chemotherapy
    1. 8
    2. 2
    3. Pages: 107-111
  4. Type of Article: Article
  1. Abstract:

    2'-Fluoro-2',3'-dideoxyarabinosyladenine (F-ddA), an anti-human immunodeficiency virus (HIV) drug currently in clinical trial, was compared with zidovudine (ATT), ddl and ddC for anti-HIV activity and potency in HIV-1 strains both sensitive and resistant to zidovudine, ddl and non-nucleoside reverse transcriptase inhibitors. A variety of host cell systems [MT-2, MT-4, phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC)] was used. F-ddA was effective against each of the drug-resistant isolates, including the strain resistant to ddl, the other purine dideoxynucleoside evaluated in this study. The anti-HIV-1 activities of F-ddA and zidovudine were also determined against clades A-E in PHA-PBMCs. Although activities were similar, zidovudine was significantly more potent than F-ddA in the PHA-PBMC system. [References: 28]

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