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Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

  1. Author:
    Su, Ting
    Qiu, Ye
    Hua, Xuesi
    Ye, Bi
    Luo, Haoming
    Liu, Da
    Qu, Peng
    Qiu, Zhidong

  2. Author Address

    Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China.Univ Michigan, Coll Literature Sci & Arts, Ann Arbor, MI 48109 USA.NCI, Frederick, MD 21701 USA.
    1. Year: 2020
    2. Date: DEC 22
    3. Epub Date: 2020 12 22
  2. Journal: Frontiers in microbiology
  3. FRONTIERS MEDIA SA,
    1. 11
  5. Type of Article: Review
  6. Article Number: 610070
  7. ISSN: 1664-302X
  1. Abstract:

    Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.3389/fmicb.2020.610070
  3. PMID: 33414777
  4. PMCID: PMC7782309
  5. View record in Web of Science®
  6. WOS: 000604606100001

Library Notes

  1. Fiscal Year: FY2020-2021
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