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Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge

  1. Author:
    Kang, Unwoo
    Wang,Dongdong
    Bokesch, Heidi R.
    Gustafson,Kirk
  2. Author Address

    Natl Canc Inst, Ctr Canc Res, Mol Targets Program, Frederick, MD 21702 USA.Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21702 USA.
    1. Year: 2021
    2. Date: Jan
  1. Journal: Chemical & pharmaceutical bulletin
  2. PHARMACEUTICAL SOC JAPAN,
    1. 69
    2. 1
    3. Pages: 48-51
  3. Type of Article: Article
  4. ISSN: 0009-2363
  1. Abstract:

    Four new pregnane steroids, 311,413,16/4-trihydroxypregna-5,17-diene-10,2-carbolactone (1), 16 beta-acetoxy3 beta,4 beta-dihydroxypregna-5,17-diene-10,2-carbolactone (2), 12 beta-acetoxy-3 beta,4 beta,16 beta-trihydroxypregna-5,17-diene-10,2-carbolactone 0), and 12 beta,16 beta-diacetoxy-3 beta,4 beta-dihydroxypregna-5,17-diene-10,2-carbolactone (4) were isolated from an extract of an Epipolasis sp. marine sponge. The structures of the new compounds were determined by extensive NMR spectroscopic analysis and comparison with data from previously reported compounds.

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External Sources

  1. DOI: 10.1248/cpb.c20-00128
  2. PMID: 33390521
  3. WOS: 000604910700008

Library Notes

  1. Fiscal Year: FY2020-2021
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