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Heterobifunctional molecules tackle targeted protein dephosphorylation

  1. Author:
    Sibley, Christopher D
    Schneekloth, John S

  2. Author Address

    Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: schneeklothjs@mail.nih.gov.,
    1. Year: 2022
    2. Date: Jan 28
  2. Journal: Trends in Pharmacological Sciences
  4. Type of Article: Article
  1. Abstract:

    Recently, Chen and colleagues reported the development of phosphatase-targeting chimeric molecules (PhosTACs), heterobifunctional small molecules that promote targeted, proximity-induced protein dephosphorylation. This strategy represents an innovative approach to selectively manipulate phosphoprotein function and provides proof-of-concept for a new class of bifunctional small molecules in the chemical biologist's toolbox. Copyright © 2022. Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tips.2022.01.005
  3. PMID: 35101278
  4. PII : S0165-6147(22)00006-2

Library Notes

  1. Fiscal Year: FY2021-2022
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