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Organization of the mouse microfibril-associated glycoprotein-2 (MAGP-2) gene

  1. Author:
    Frankfater, C.
    Maus, E.
    Gaal, K.
    Segade, F.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Shipley, J. M.

  2. Author Address

    Shipley JM Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Med,Div Pulm & Crit Care Med 216 S Kingshighway Blvd St Louis, MO 63110 USA Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Med,Div Pulm & Crit Care Med St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Cell Biol St Louis, MO 63110 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Mammalian Genome
    1. 11
    2. 3
    3. Pages: 191-195
  4. Type of Article: Article
  1. Abstract:

    A 1.4-kb EST clone encoding mouse microfibril-associated glycoprotein-2 (MAGP-2), identified by its similarity with the reported human cDNA, was used to screen a mouse 129 genomic bacterial artificial chromosome (BAC) library. The mouse gene contains 10 exons spanning 16 kb, located on the distal region of Chromosome (Chr) 6. The exons range in size from 24 to 963 bp, with the ATG located in exon 2. The tenth and largest exon contains 817 bp of 3' untranslated sequence, including a B2 repetitive element. Northern analysis demonstrates abundant expression of MAGP-2 mRNA in skeletal muscle, lung, and heart. Sequence analysis of additional cDNA clones suggests that the two mRNA forms of MAGP-2 in the mouse arise from alternative polyadenylation site usage. The promoter does not contain an obvious TATA box, and the sequence surrounding the start site does not conform to the consensus for an initiator promoter element. Additionally, the mouse promoter contains 22 copies of a CT dinucleotide repeat sequence located similar to 155 bp 5' to exon 1. [References: 20]

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