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IL-4, IL-13 and IFN-gamma induced genes in highly purified human neutrophils

  1. Author:
    Kummola, Laura
    Salomaa, Tanja
    Ortutay, Zsuzsanna
    Savan, Ram
    Young,Howard
    Junttila, Ilkka S

  2. Author Address

    Biodiversity Interventions for Well-being, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland., Cytokine Biology Research Group, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland; Fimlab Laboratories, 33520 Tampere, Finland., HiDucator Oy, 36200 Kangasala, Finland., Department of Immunology, School of Medicine, University of Washington, 98195 Seattle, WA, USA., Center for Cancer Research, National Cancer Institute, 21702 Frederick, MD, USA., Cytokine Biology Research Group, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland; Fimlab Laboratories, 33520 Tampere, Finland; Northern Finland Laboratory Centre (NordLab), 90220 Oulu, Finland; Research Unit of Biomedicine, University of Oulu, 90570 Oulu, Finland. Electronic address: ilkka.junttila@tuni.fi.,
    1. Year: 2023
    2. Date: Feb 19
    3. Epub Date: 2023 02 19
  2. Journal: Cytokine
    1. 164
    2. Pages: 156159
  4. Type of Article: Article
  5. Article Number: 156159
  1. Abstract:

    Interleukin (IL)-4 and IL-13 are related cytokines with well-known specific roles in type 2 immune response. However, their effects on neutrophils are not completely understood. For this, we studied human primary neutrophil responses to IL-4 and IL-13. Neutrophils are dose-dependently responsive to both IL-4 and IL-13 as indicated by signal transducer and activator of transcription 6 (STAT6) phosphorylation upon stimulation, with IL-4 being more potent inducer of STAT6. IL-4-, IL-13- and Interferon (IFN)-gamma-stimulated gene expression in highly purified human neutrophils induced both overlapping and unique gene expression in highly purified human neutrophils. IL-4 and IL-13 specifically regulate several immune-related genes, including IL-10, tumor necrosis factor (TNF) and leukemia inhibitory factor (LIF), while type1 immune response-related IFN-gamma induced gene expression related for example, to intracellular infections. In analysis of neutrophil metabolic responses, oxygen independent glycolysis was specifically regulated by IL-4, but not by IL-13 or IFN-gamma, suggesting specific role for type I IL-4 receptor in this process. Our results provide a comprehensive analysis of IL-4, IL-13 and IFN-gamma -induced gene expression in neutrophils while also addressing cytokine-mediated metabolic changes in neutrophils. Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.cyto.2023.156159
  3. PMID: 36809715
  4. PII : S1043-4666(23)00037-6

Library Notes

  1. Fiscal Year: FY2022-2023
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