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Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of Ferula turcica

  1. Author:
    Eruçar, Fatma Memnune [ORCID]
    Senadeera, Sarath P D
    Wilson,Jennifer
    Goncharova,Katya
    Beutler,John [ORCID]
    Miski, Mahmut

  2. Author Address

    Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Türkiye. Department of Pharmacognosy, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul 34116, Türkiye. Molecular Targets Program, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA. Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
    1. Year: 2023
    2. Date: Jul 28
    3. Epub Date: 2023 07 28
  2. Journal: Molecules (Basel, Switzerland)
    1. 28
    2. 15
  4. Type of Article: Article
  5. Article Number: 5733
  1. Abstract:

    Six new sesquiterpene coumarin ethers, namely turcicanol A (1), turcicanol A acetate (2), turcicanol B (3), turcica ketone (4), 11 39;-dehydrokaratavicinol (5), and galbanaldehyde (6), and one new sulfur-containing compound, namely turcicasulphide (7), along with thirty-two known secondary metabolites were isolated from the root of the endemic species Ferula turcica Akalin, Miski, & Tuncay through a bioassay-guided isolation approach. The structures of the new compounds were elucidated by spectroscopic analysis and comparison with the literature. Cell growth inhibition of colon cancer cell lines (COLO205 and HCT116) and kidney cancer cell lines (UO31 and A498) was used to guide isolation. Seventeen of the compounds showed significant activity against the cell lines.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules28155733
  3. PMID: 37570703
  4. PMCID: PMC10420993
  5. PII : molecules28155733

Library Notes

  1. Fiscal Year: FY2022-2023
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