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Molecular characterization of a recombinant HIV type 1 isolate (A/G/E/?): Unidentified regions may be derived from parental subtype E sequences

  1. Author:
    Paraskevis, D.
    Magiorkinis, M.
    Paparizos, V.
    Pavlakis, G. N.
    Hatzakis, A.
  2. Author Address

    Hatzakis A Univ Athens, Sch Med, Dept Hyg & Epidemiol, Natl Retrovirus Reference Ctr GR-11527 Athens Greece Univ Athens, Sch Med, Dept Hyg & Epidemiol, Natl Retrovirus Reference Ctr GR-11527 Athens Greece Univ Athens, Andreas Syngros Hosp, Sch Med, Dept Dermatol Venereol GR-16121 Athens Greece NCI, ABL Basic Res Program, FCRDC Frederick, MD 21702 USA
    1. Year: 2000
  1. Journal: Aids Research and Human Retroviruses
    1. 16
    2. 9
    3. Pages: 845-855
  2. Type of Article: Article
  1. Abstract:

    Recombination is one of several factors contributing to the genetic diversity of HIV-1, which is divided into group M (itself comprising 11 subtypes, A-K) and two other groups named O and N, In the present study, the full-length genome of an HIV-1 isolate obtained from a Greek subject (GR17) infected in the Democratic Republic of the Congo (formerly Zaire) was analyzed to reveal a novel mosaic sequence composed of subtypes A, G, and E and regions of indeterminate classification, In particular, most of pol and tat/vpu, as well as the region encoding intracellular domain of gp41, did not cluster with any of the previously characterized HIV-1 subtypes, The clustering of the LTR of GR17 with subtype E was suggestive of a subtype E origin of the unclassified regions. However, the identification of distinct characteristics in the LTR, such as two functional NF-kappa B sites and a distinct TAR element, compared with those of circulating (A/E) recombinants, suggests that the partial subtype E sequences found in GR17 and the mosaic viruses (A/E) have not derived from each other, These results provide evidence that parental subtype E may have existed in the geographic area of Central Africa. [References: 29]

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