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Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra

  1. Author:
    Rashid, M. A.
    Gustafson, K. R.
    Boswell, J. L.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr Bldg 1052,Room 121 Frederick, MD 21702 USA NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA Frederick Canc Res & Dev Ctr, SAIC Frederick Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Journal of Natural Products
    1. 63
    2. 7
    3. Pages: 956-959
  4. Type of Article: Article
  1. Abstract:

    Bioassay-guided fractionation of a cytotoxic aqueous extract of the sponge Haliclona nigra provided two new cyclic hexapeptides, haligramides A (1) and B (2), in addition to the known peptide, waiakeamide (3). The structures of peptides 1 and 2 were elucidated by extensive NMR analyses and by comparison of their spectral data with those of waiakeamide (3). The identity of haligramide A (1) was confirmed by its oxidative conversion to waiakeamide (3). Further structural confirmation was provided by oxidation of peptides 1, 2, and 3 to the common bis-sulfone derivative 4. [References: 21]

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