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Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin

  1. Author:
    Saavedra, J. E.
    Mooradian, D. L.
    Mowery, K. A.
    Schoenfisch, M. H.
    Citro, M. L.
    Davies, K. M.
    Meyerhoff, M. E.
    Keefer, L. K.

  2. Author Address

    Keefer LK NCI, Frederick Canc Res & Dev Ctr, Comparat Carcinogenesis Lab, Chem Sect Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Comparat Carcinogenesis Lab, Chem Sect Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Intramural Res Support Program, SAIC Frederick Frederick, MD 21702 USA Univ Minnesota, Dept Biomed Engn, Blood & Biocompatibil Res Lab Minneapolis, MN 55455 USA Univ Michigan, Dept Chem Ann Arbor, MI 48109 USA George Mason Univ, Dept Chem Fairfax, VA 22030 USA
    1. Year: 2000
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 10
    2. 8
    3. Pages: 751-753
  4. Type of Article: Article
  1. Abstract:

    We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics. Published by Elsevier Science Ltd. [References: 9]

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