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Combining a rhesus cytomegalovirus/SIV vaccine with neutralizing antibody to protect against SIV challenge in rhesus macaques

  1. Author:
    Coppola, Jessica
    Parren, Mara
    Bastidas, Raiza
    Saye, Karen
    Malvin, Jacqueline
    Jardine, Joseph
    Gilbride, Roxanne
    Ojha, Sohita
    Feltham, Shana
    Morrow, David
    Barber-Axthelm, Aaron
    Bochart, Rachele
    Fast, Randy
    Oswald, Kelli
    Shoemaker, Rebecca
    Lifson, Jeffrey
    Picker, Louis
    Burton, Dennis
    Hansen, Scott

  2. Author Address

    1Department of Immunology and Microbiology, Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037 USA. 2Vaccine & Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. 3AIDS and Cancer Virus Program, Frederick National Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America Vaccine and Infectious Disease Division.
    1. Year: 2025
    2. Date: Apr 1
  2. Journal: bioRxiv
  4. Type of Article: Article
  1. Abstract:

    A vaccine is widely regarded as necessary for the control of the HIV pandemic and eventual eradication of AIDS. Neutralizing antibodies and MHC-E-restricted CD8+ T cells have both been shown capable of vaccine protection against the simian counterpart of HIV, SIV, in rhesus macaques. Here we provide preliminary evidence that combining these orthogonal antiviral mechanisms can provide increased protection against SIV challenge such that replication arrest observed following vaccination with a rhesus cytomegalovirus (RhCMV/SIV)-based vaccine was enhanced in the presence of passively administered incompletely protective levels of neutralizing antibody. The report invites studies involving larger cohorts of macaques and alternate routes of providing neutralizing antibody.

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External Sources

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  2. DOI: 10.1101/2025.03.20.644395
  3. PMID: 40196580
  4. PMCID: PMC11974736

Library Notes

  1. Fiscal Year: FY2024-2025
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