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Lyciumines A and B: Two Pyrrole-Fused Alkaloids from the Fruits of Lycium barbarum

  1. Author:
    Zhu, Yan-Jie
    Dai, Xiang-Yang
    Zhao, Yi-Lin
    Ma, Yu-Guo
    Zhao, Zhen-Zhu [ORCID]
    Su, Cheng-Fu
    Hao, Zhi-You [ORCID]
    Wang,Dongdong [ORCID]
    Chen, Hui [ORCID]

  2. Author Address

    School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, People's Republic of China., Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of People's Republic of China, Zhengzhou 450046, People's Republic of China.,
    1. Year: 2025
    2. Date: May 04
    3. Epub Date: 2025 05 04
  2. Journal: Journal of Natural Products
  4. Type of Article: Article
  1. Abstract:

    Two novel pyrrole-fused alkaloids, lyciumines A (1) and B (2), were isolated from the fruits of Lycium barbarum. Their structures were elucidated by analysis of NMR spectroscopic and MS spectrometric data, along with computational studies. Compound 1 represents a novel pyrroloindoline alkaloid with a rare 6/5/5/6 tetracyclic system connected with a 2-formyl-5-methylpyrrole moiety via a C-C bond. Compound 2 features an unusual pyrrole alkaloid with a 5/5/5 tricyclic skeleton. Compound 1 significantly increases glucose consumption in insulin-resistant HepG2 cells in a dose-dependent manner. Further mechanism investigations demonstrated that compound 1 regulates glucose metabolism via activating the AMPK/PI3K/Akt signaling pathway.

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External Sources

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  2. DOI: 10.1021/acs.jnatprod.5c00385
  3. PMID: 40320641

Library Notes

  1. Fiscal Year: FY2024-2025
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