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Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to Type 2 phosphatidic acid phosphatases

  1. Author:
    Zhang, N. A.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Gridley, T.

  2. Author Address

    Gridley T Jackson Lab 600 Main St Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor, ME 04609 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Genomics
    1. 63
    2. 1
    3. Pages: 142-144
  4. Type of Article: Article
  1. Abstract:

    The wunen gene of Drosophila melanogaster encodes a multipass membrane-spanning protein that negatively regulates primordial germ cell migration. Here we describe the cloning of a mouse gene that encodes a protein homologous to wunen and to the Type 2 phosphatidic acid phosphatases, This gene encodes a 251-amino-acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c, Northern blot analysis revealed the presence of a single 1.9-kb Ppap2c transcript. The Ppap2c gene was localized to the central portion of mouse Chromosome 10 by interspecific backcross analysis, (C) 2000 Academic Press. [References: 13]

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