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The induction of skeletal muscle hypertrophy by a ski transgene is promoter-dependent

  1. Author:
    Sutrave, P.
    Leferovich, J. M.
    Kelly, A. M.
    Hughes, S. H.

  2. Author Address

    Hughes SH NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA Univ Penn, Sch Vet Med, Dept Pathobiol Philadelphia, PA 19104 USA
    1. Year: 2000
  2. Journal: Gene
    1. 241
    2. 1
    3. Pages: 107-116
  4. Type of Article: Article
  1. Abstract:

    The chicken c-ski gene expresses at least three alternatively spliced messages. Transgenic mice expressing proteins from cDNA corresponding to two of these messages (FB27 and FB29) under the control of a murine sarcoma virus (MSV) long terminal repeat (LTR) express the transgene in skeletal muscle and develop a muscular phenotype. Both a biologically active form of c-ski and the MSV LTR are required for the development of the muscular phenotype. The normal c-ski gene linked to two other tissue-specific promoters failed to induce muscle growth in transgenic mice, as did an inactive mutant of c-ski expressed under the control of the MSV LTR. (C) 2000 Elsevier Science B.V. All rights reserved. [References: 32]

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