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Oct-4, scene 1: the drama of mouse development

  1. Author:
    Stewart, C. L.

  2. Author Address

    Stewart CL NCI, Frederick Canc Res & Dev Ctr, Lab Canc & Dev Biol Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Canc & Dev Biol Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Nature Genetics
    1. 24
    2. 4
    3. Pages: 328-330
  4. Type of Article: Article
  1. Abstract:

    A study by Niwa et al. shows that changes in the levels of the transcription factor Oct-4 regulate the differentiation of embryonic stem cells along three different pathways. These observations suggest a possible mechanism by which Oct-4 determines the formation of the mouse pre-implantation embryo. [References: 10]

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