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Oct-4, scene 1: the drama of mouse development

Author:

Stewart, C. L.
Author Address

Stewart CL NCI, Frederick Canc Res & Dev Ctr, Lab Canc & Dev Biol Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Canc & Dev Biol Frederick, MD 21702 USA

1. Year: 2000
Journal: Nature Genetics
1. Volume: 24
2. Issue: 4
3. Pages: 328-330
Type of Article: Article

Abstract:

A study by Niwa et al. shows that changes in the levels of the transcription factor Oct-4 regulate the differentiation of embryonic stem cells along three different pathways. These observations suggest a possible mechanism by which Oct-4 determines the formation of the mouse pre-implantation embryo. [References: 10]

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