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Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP

  1. Author:
    Taylor, G. A.
    Collazo, C. M.
    Yap, G. S.
    Nguyen, K.
    Gregorio, T. A.
    Taylor, L. S.
    Eagleson, B.
    Secrest, L.
    Southon, E. A.
    Reid, S. W.
    Tessarollo, L.
    Bray, M.
    McVicar, D. W.
    Komschlies, K. L.
    Young, H. A.
    Biron, C. A.
    Sher, A.
    Vande Woude, G. F.

  2. Author Address

    Vande Woude GF Van Andel Res Inst 201 Monroe Ave,Suite 400 Grand Rapids, MI 49503 USA NCI, Frederick Canc Res & Dev Ctr, Adv Biosci Labs, Basic Res Program Frederick, MD 21702 USA NIAID, Parasit Dis Lab, Immunobiol Sect, NIH Bethesda, MD 20892 USA Brown Univ, Div Biol & Med, Dept Mol Microbiol & Immunol Providence, RI 02912 USA Sci Applicat Int Corp, Intramural Res Support Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Cellular & Mol Immunol Sect, Expt Immunol Lab Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci Frederick, MD 21702 USA USA, Med Res Inst Infect Dis Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 97
    2. 2
    3. Pages: 751-755
  4. Type of Article: Article
  1. Abstract:

    Interferon-gamma (IFN-gamma) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of IFN-gamma-regulated genes that encode 48-kDa CTP-binding proteins that localize to the endoplasmic reticulum. We have generated IGTP-deficient mice and found that, despite normal immune cell development and normal clearance of Listeria monocytogenes and cytomegalovirus infections, the mice displayed a profound loss of host resistance to acute infections of the protozoan parasite Toxoplasma gondii. By contrast, IFN-gamma receptor-deficient mice have increased susceptibility to all three pathogens. Thus, IGTP defines an IFN-gamma-regulated pathway with a specialized role in antimicrobial resistance. [References: 27]

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