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Regulation and function of the p53-related proteins: same family, different rules

  1. Author:
    Lohrum, M. A. E.
    Vousden, K. H.

  2. Author Address

    Lohrum MAE NCI, Regulat Cell Growth Lab, FCRDC Bldg 560,Room 22-96,W 7th St Frederick, MD 21702 USA NCI, Regulat Cell Growth Lab, FCRDC Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Trends in Cell Biology
    1. 10
    2. 5
    3. Pages: 197-202
  4. Type of Article: Review
  1. Abstract:

    The tumour-suppressor protein p53 has recently been shown to belong to a family that includes two structurally related proteins, p63 and p73. Although all three proteins share similar transcriptional functions and the ability to induce apoptosis, each of them appears to play a distinct role in development and tumour suppression, In order for cell division to occur, the antiproliferative activities of these proteins must be tightly controlled, and exciting advances have been mane in our understanding of the pathways involved in regulating p53 activity. [References: 60]

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