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Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore

  1. Author:
    McNulty, J.
    Mao, J.
    Gibe, R.
    Mo, R. W.
    Wolf, S.
    Pettit, G. R.
    Herald, D. L.
    Boyd, M. R.

  2. Author Address

    Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada. Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada. Arizona State Univ, Canc Res Inst, Tempe, AZ 85287 USA. Arizona State Univ, Dept Chem, Tempe, AZ 85287 USA. NCI, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA. McNulty J Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada.
    1. Year: 2001
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 11
    2. 2
    3. Pages: 169-172
  4. Type of Article: Article
  1. Abstract:

    Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures. (C) 2001 Elsevier Science Ltd. All rights reserved.

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