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New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species

  1. Author:
    Meragelman, K. M.
    McKee, T. C.
    Boyd, M. R.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick, MD 21702 USA. Boyd MR NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Div Basic Sci, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Journal of Natural Products
    1. 64
    2. 3
    3. Pages: 389-392
  4. Type of Article: Article
  1. Abstract:

    Three new isomalabaricane triterpenes, 29-hydroxystelliferin E (1), 29-hydroxystelliferin A (2), and stelliferin G (3), together with the known triterpene 3-epi-29-tiydroxystelliferin E (4), were isolated from the organic extract of the sponge Jaspis sp. collected in the South Pacific. All the compounds isolated showed antiproliferative activity against melanoma cells (MALME-3M).

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