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Anti-HIV prenylated flavonoids from Monotes africanus

  1. Author:
    Meragelman, K. M.
    McKee, T. C.
    Boyd, M. R.

  2. Author Address

    NCI, Div Basic Sci, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA. NCI, Div Basic Sci, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA. Boyd MR NCI, Div Basic Sci, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Journal of Natural Products
    1. 64
    2. 4
    3. Pages: 546-548
  4. Type of Article: Article
  1. Abstract:

    Six flavonoids, among them a new dihydroflavonol, 6,8- diprenylaromadendrin (1), and the flavonol. 6,8- diprenylkaempferol (3), have been isolated from the organic extract of Monotes africanus. The isolated compounds containing a 5,7-dihydroxy-6,8-diprenyl system in the A ring of the flavonoid (1, 3, and 6) exhibited HIV-inhibitory activity in the XTT-based, whole-cell screen. In addition, several C-13 NMR assigments of lonchocarpol A (6) were corrected.

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