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Comparative characterization of lymphotoxin transcripts from human B- and T-cell lines, peripheral lymphocytes, and normal tissues

  1. Author:
    Boitchenko, V. E.
    Alimzhanov, M. B.
    Turetskaya, R. L.
    Ruhlmann, A.
    Nordheim, A.
    Kuprash, D. V.
    Nedospasov, S. A.

  2. Author Address

    Belozerskii Inst Physicochem Biol, Moscow 119899, Russia. Belozerskii Inst Physicochem Biol, Moscow 119899, Russia. Moscow State Univ, Ctr Mol Med, Moscow 119899, Russia. Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia. Univ Tubingen, Inst Cell Biol, D-72076 Tubingen, Germany. NCI, Frederick, MD 21702 USA. Boitchenko VE Belozerskii Inst Physicochem Biol, Moscow 119899, Russia.
    1. Year: 2001
  2. Journal: Molecular Biology
    1. 35
    2. 1
    3. Pages: 115-121
  4. Type of Article: Article
  1. Abstract:

    Membrane lymphotoxin (LT) is a heterotrimer LT alpha (1)beta (2), and its production depends on two genes. Northern blotting was employed in studying their transcription in human B- and T- lymphoma cell lines and in peripheral blood lymphocytes before and after induction with phorbol myristate acetate (PMA). Transcription of either gene proved to be similarly regulated in several cell lines and in blood lymphocytes. Activation of the LT alpha gene was associated with induction of transcription factor NF-kappaB (p50/p65) upon cell treatment with PMA. On evidence of RT-PCR, two transcripts of the LTP gene were present in equimolar amounts in all lymphoid cells. A product of alternative splicing contained an open reading frame coding for the cytoplasmic portion of LTP.

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