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PUMA, a novel proapoptotic gene, is induced by p53

  1. Author:
    Nakano, K.
    Vousden, K. H.

  2. Author Address

    NCI, Regulat Cell Growth Lab, Frederick, MD 21702 USA. NCI, Regulat Cell Growth Lab, Frederick, MD 21702 USA. Vousden KH NCI, Regulat Cell Growth Lab, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Molecular Cell
    1. 7
    2. 3
    3. Pages: 683-694
  4. Type of Article: Article
  1. Abstract:

    The p53 tumor-suppressor protein functions as a transcriptional activator, and several p53-inducible genes that play a role in the induction of apoptosis in response to p53 have been described. We have identified a novel gene named PUMA (p53 upregulated modulator of apoptosis) as a target for activation by p53. This gene encodes two BH3 domain-containing proteins (PUMA-alpha and PUMA-beta) that are induced in cells following p53 activation. PUMA-a( and PUMA-P show similar activities; they bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

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