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Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species

  1. Author:
    Charan, R. D.
    McKee, T. C.
    Boyd, M. R.

  2. Author Address

    NCI, Ctr Canc Res, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA. NCI, Ctr Canc Res, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Journal of Natural Products
    1. 64
    2. 5
    3. Pages: 661-663
  4. Type of Article: Article
  1. Abstract:

    Two new sesterterpenes, thorectandrol A (1) and B (2), were isolated from extracts of the marine sponge Thorectandra sp. The structures were determined by extensive NMR spectral data analysis. NOE correlations were used to define the relative stereochemistry of 1 and 2, while CD data were used to suggest their absolute stereochemistry. Both compounds 1 and 2 inhibited the growth of MALME-3M (melanoma) and MCF-7 (breast) cancer cell lines in the range 30-40 mug/mL. The known compound palauolol (3) was isolated as well and was also cytotoxic.

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