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Cadmium-induced malignant transformation of human prostate epithelial cells

  1. Author:
    Achanzar, W. E.
    Diwan, B. A.
    Liu, J.
    Quader, S. T.
    Webber, M. M.
    Waalkes, M. P.

  2. Author Address

    NIEHS, Inorgan Carcinogenesis Sect, Comparat Carcinogenesis Lab, NCI, MD F0-09, 111 Alexander Dr, Res Triangle Pk, NC 27709 USA. NIEHS, Inorgan Carcinogenesis Sect, Comparat Carcinogenesis Lab, NCI, Res Triangle Pk, NC 27709 USA. NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp Frederick, Intramural Res Support Program, Frederick, MD 21702 USA. Michigan State Univ, Dept Med, E Lansing, MI 48824 USA. Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA. Waalkes MP NIEHS, Inorgan Carcinogenesis Sect, Comparat Carcinogenesis Lab, NCI, MD F0-09, 111 Alexander Dr, Res Triangle Pk, NC 27709 USA.
    1. Year: 2001
  2. Journal: Cancer Research
    1. 61
    2. 2
    3. Pages: 455-458
  4. Type of Article: Article
  1. Abstract:

    Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by ill vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition irt vitro and rapidly formed highly invasive and occasionally metastatic adenocarcinomas upon inoculation into mice. The transformed cells also showed increased secretion of MMP-2 and MMP-9, a phenomenon observed in human prostate tumors and linked to aggressive behavior. Cadmium-induced malignant transformation of human prostate epithelial cells strongly fortifies the evidence for a potential role of cadmium in prostate cancer.

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