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Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba- pseudoribose rings

  1. Author:
    Ravi, G.
    Lee, K.
    Ji, X. D.
    Kim, H. S.
    Soltysiak, K. A.
    Marquez, V. E.
    Jacobson, K. A.

  2. Author Address

    NIDDK, Mol Recognit Sect, LBC, NIH, Bethesda, MD 20892 USA. NIDDK, Mol Recognit Sect, LBC, NIH, Bethesda, MD 20892 USA. NCI, Med Chem Lab, Frederick, MD 21702 USA. Jacobson KA NIDDK, Mol Recognit Sect, LBC, NIH, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 11
    2. 17
    3. Pages: 2295-2300
  4. Type of Article: Article
  1. Abstract:

    6-Oxopurine derivatives containing a northern (N) methanocarba modification (i.e., fused cyclopropane and cyclopentane rings in place of the ribose) were synthesized and the adenosine receptor affinity measured. Guanine or hypoxanthine was coupled at the 7-position, or 1,3-diblitylxanthine was coupled at the 9-position. The pseudoribose ring was also substituted at the 5 ' -position with an N-methyluronamide or with phosphate groups. Published by Elsevier Science Ltd.

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