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Hematopoietic switch from lymphoid to granulocytic development in 3LL tumor-bearing mice

  1. Author:
    Lee, J. K.
    Back, T. C.
    Komschlies, K. L.
    Ruscetti, F. W.
    Young, H. A.
    Wiltrout, R. H.

  2. Author Address

    NCI, Expt Therapeut Sect, LEI, Bldg 560, Room 31-93, Frederick, MD 21702 USA. NCI, Expt Therapeut Sect, LEI, Frederick, MD 21702 USA. NCI, Lab Leukocyte Biol, Frederick, MD 21701 USA. SAIC Frederick, Intramural Res Support Program, Frederick, MD USA. Wiltrout RH NCI, Expt Therapeut Sect, LEI, Bldg 560, Room 31-93, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: In Vivo
    1. 15
    2. 4
    3. Pages: 255-263
  4. Type of Article: Article
  1. Abstract:

    A significant splenomegaly and lymphadenopathy develops during the progressive growth of Lewis Lung (3LL) tumors in mice. Enlarged spleen and lymph nodes occur because of a pronounced increase in granulocytes in these organs. This granulocytosis in spleen and lymph node was not simply due to recruitment of granulocytes from peripheral blood to spleen and lymph nodes, but also a result of development and/or differentiation of granulocytes from the bone marrow. There was a marked increase in development of myeloid lineage cells, whereas lymphoid populations including T cells and B cells, were dramatically decreased in bone marrow and peripheral blood of 3LL tumor- beating mice. These data demonstrate that host hematopoiesis shifts from lymphoid to granulocytic development in the 3LL tumor-beating mice. Interestingly, a somatic mutation of N-Ras gene was found in 3LL tumor cells at codon 61, suggesting that mutated N-Ras may contribute to induction of granulocytosis in 3LL tumor-bearing mice.

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