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From cytosol to mitochondria: The Bax translocation story

  1. Author:
    Khaled, A. R.
    Durum, S. K.

  2. Author Address

    NCI, Ctr Canc Res, Mol Immunoregulat Lab, Frederick, MD 21702 USA. NCI, Ctr Canc Res, Mol Immunoregulat Lab, Frederick, MD 21702 USA. Durum SK NCI, Ctr Canc Res, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Journal of Biochemistry and Molecular Biology
    1. 34
    2. 5
    3. Pages: 391-394
  4. Type of Article: Review
  1. Abstract:

    The balance between life and death of a cell regulates essential developmental processes in multicellular organisms. Apoptotic cell death is a complex, stepwise program involving multiple protein components that trigger and execute the demise of the cell. Of the many triggers of apoptosis, most are not well understood, but some key components have been identified, such as those of the Bcl-2 family, which function as anti- apoptotic or pro-apoptotic factors. Bax, a pro-apoptotic member of this family, has been shown to serve as a component of many apoptotic triggering cascades and its mechanism of action is the focus of intense study. Herein we discuss current, differing ideas on the function of Bax and its structure, and suggest novel mechanisms for how this death protein targets mitochondria, triggering apoptosis.

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