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Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challenge

  1. Author:
    Lifson, J. D.
    Piatak, M.
    Rossio, J. L.
    Bess, J.
    Chertova, E.
    Schneider, D.
    Kiser, R.
    Coalter, V.
    Poore, B.
    Imming, R.
    Desrosiers, R. C.
    Henderson, L. E.
    Arthur, L. O.

  2. Author Address

    NCI, SAIC Frederick, AIDS Vaccine Program, Bldg 535,5th Floor, Frederick, MD 21702 USA NCI, SAIC Frederick, AIDS Vaccine Program, Frederick, MD 21702 USA Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Southborough, MA 01772 USA Lifson JD NCI, SAIC Frederick, AIDS Vaccine Program, Bldg 535,5th Floor, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Journal of Medical Primatology
    1. 31
    2. 4-5
    3. Pages: 205-216
  4. Type of Article: Article
  1. Abstract:

    A novel type of whole inactivated simian immunodeficiency virus (SIV) virion vaccine immunogen with functional envelope glycoproteins was evaluated, without adjuvant, in rhesus macaques. Immunogens included purified inactivated virions of SIVmac239, a designed mutant of SIVmac239 with gp120 carbohydrate attachment sites deleted (SIVmac239 g4,5), and SIVmneE11S. The vaccines were noninfectious, safe, and immunogenic, inducing antibody responses and cellular responses, including responses by CD8+ lymphocytes. Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naive controls.

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