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Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp

  1. Author:
    Pettit, G. R.
    Ducki, S.
    Tan, R.
    Gardella, R. S.
    McMahon, J. B.
    Boyd, M. R.
    Blumberg, P. M.
    Lewin, N. E.
    Doubek, D. L.
    Tackett, L. P.
    Williams, M. D.

  2. Author Address

    Arizona State Univ, Canc Res Inst, Tempe, AZ 85287 USA Arizona State Univ, Canc Res Inst, Tempe, AZ 85287 USA Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA NCI, Sci Applicat Int Corp, Frederick, MD 21702 USA NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA NCI, Cellular Carcinogenesis & Tumor Promot Lab, Bethesda, MD 20892 USA Pettit GR Arizona State Univ, Canc Res Inst, Tempe, AZ 85287 USA
    1. Year: 2002
  2. Journal: Journal of Natural Products
    1. 65
    2. 9
    3. Pages: 1262-1265
  4. Type of Article: Article
  1. Abstract:

    A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be 13-O-acetyl-12-O-[2'Z,4'E- octadienoyl]-4alpha-deoxyphorbol on the basis of high- resolution mass spectral and 2D NMR assignments. Pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED50 of 0.28 mug/mL, to afford, at concentrations of 2-5 muM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a K-i of 620 +/- 20 nM.

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