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Inhibition of Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration By Ets1 Antisense Oligonucleotides

  1. Author:
    Chen, Z. Q.
    Fisher, R. J.
    Riggs, C. W.
    Rhim, J. S.
    Lautenberger, J. A.

  2. Author Address

    Lautenberger JA NCI FREDERICK CANC RES & DEV CTR SCI APPLICAT INT CORP POB B BLDG 560 ROOM 21-49 FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR SCI APPLICAT INT CORP FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR DATA MANAGEMENT SERV FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR LAB BIOCHEM PHYSIOL FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR LAB GENOM DIVERS FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Cancer Research
    1. 57
    2. 10
    3. Pages: 2013-2019
  4. Type of Article: Article
  1. Abstract:

    Vascular endothelial growth factor (VEGF) increased the level of ETS1 mRNA in human umbilical vein endothelial cells (HUVEC) and human lung microvascular endothelial cells (HMVEC-L) over 5-fold. Protein levels were shown to increase concordantly. VEGF was also found to stimulate the invasiveness of endothelial cells as measured by migration through Matrigel- or gelatin-coated membranes. The VEGF-induced invasiveness was inhibited by ETS1 antisense oligonucleotides but not by a sense control. In addition, the ETS1 antisense oligonucleotides reduced the levels of ETS1 and urokinase-type plasminogen activator mRNAs. The antisense oligonucleotides directed against the ETS1 gene thus altered a cellular property of endothelial cells that is correlated with the ability of the cells to migrate through basement membranes. Together, these observations demonstrate a direct role for the ETS1 gene in angiogenesis. [References: 37]

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