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Unusual sulfamate indoles and a novel indolo 3,2-a carbazole from Ancorina sp

  1. Author:
    Meragelman, K. M.
    West, L. M.
    Northcote, P. T.
    Pannell, L. K.
    McKee, T. C.
    Boyd, M. R.

  2. Author Address

    NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA Victoria Univ Wellington, Sch Chem & Phys Sci, Wellington, New Zealand NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA Meragelman KM NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Journal of Organic Chemistry
    1. 67
    2. 19
    3. Pages: 6671-6677
  4. Type of Article: Article
  1. Abstract:

    Four new indoles, ancorinolates A-C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3, 2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3, 2-alpha]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV- inhibitory activity in the XTT-based, anticytopathicity assay.

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