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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

  1. Author:
    Collins, F. S.

  2. Author Address

    NCI, NIH, 31 Ctr Dr,Room 10A07, Bethesda, MD 20892 USA NCI, NIH, Bethesda, MD 20892 USA NHGRI, NIH, Bethesda, MD 20892 USA Natl Ctr Biotechnol Informat, Natl Lib Med, NIH, Bethesda, MD 20894 USA NCI, Ctr Bioinformat, Bethesda, MD 20892 USA Frederick Inc, SAIC, NCI, Frederick, MD 21702 USA Invitrogen Corp, Carlsbad, CA 92008 USA BD Biosci CLONTECH, Palo Alto, CA 94303 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA Univ Iowa, Iowa City, IA 52242 USA NIMH, NIH, Cell Biol Lab, Bethesda, MD 20892 USA RIKEN, Genome Sci Lab, Wako, Saitama 3510198, Japan Lawrence Livermore Natl Lab, IMAGE Consortium, Biol & Biotechnol Res Program, Livermore, CA 94550 USA Incyte Genom Inc, Palo Alto, CA 94304 USA Agencourt Biosci Corp, Beverly, MA 01915 USA Baylor Coll Med, Baylor Human Genome Sequencing Ctr, Dept Mol & Human Genet, Houston, TX 77030 USA Inst Syst Biol, Seattle, WA 98103 USA NIH, Intramural Sequencing Ctr, Gaithersburg, MD 20877 USA Stanford Univ, Stanford Human Genome Ctr, Dept Genet, Sch Med, Palo Alto, CA 94304 USA Univ British Columbia, Genome Sci Ctr, British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada Collins FS NCI, NIH, 31 Ctr Dr,Room 10A07, Bethesda, MD 20892 USA
    1. Year: 2002
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 99
    2. 26
    3. Pages: 16899-16903
  4. Type of Article: Article
  1. Abstract:

    The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones for an additional 7,800 human and 3,500 mouse genes also have been identified. All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http://mgc.nci.nih.gov).

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