Skip NavigationSkip to Content
Return Return to Search Results

In Vitro Anti-Hiv Activity of Biflavonoids Isolated From Rhus Succedanea and Garcinia Multiflora

  1. Author:
    Lin, Y. M.
    Anderson, H.
    Flavin, M. T.
    Pai, Y. H. S.
    Matagreenwood, E.
    Pengsuparp, T.
    Pezzuto, J. M.
    Schinazi, R. F.
    Hughes, S. H.
    Chen, F. C.

  2. Author Address

    Lin YM MEDICHEM RES INC 12305 S NEW AVE LEMONT, IL 60439 USA UNIV ILLINOIS DEPT MED CHEM & PHARMACOGNOSY CHICAGO, IL 60612 USA VET AFFAIRS MED CTR GEORGIA VA RES CTR AIDS & HIV INFECT DECATUR, GA 30033 USA EMORY UNIV SCH MED DECATUR, GA 30033 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD 21702 USA TAMKANG UNIV DEPT CHEM TAIPEI TAIWAN
    1. Year: 1997
  2. Journal: Journal of Natural Products
    1. 60
    2. 9
    3. Pages: 884-888
  4. Type of Article: Article
  1. Abstract:

    Eleven biflavonoids, including amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), morelloflavone (7), rhusflavanone (9), succedaneaflavanone (10), GB-1a (11), GB-1a 7 ''-O-beta-glucoside (13), and GB-2a (14) isolated from Rhus succedanea and Garcinia multifilora, as well as their methyl ethers, volkensiflavone hexamethyl ether (6), morelloflavone heptamethyl ether (8), and GB-1a hexamethyl ether (12), were evaluated for their anti-HIV-1 RT activity. The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 mu M. Compounds 1, 2, 7, 11, and 14 were moderately active against HIV-1 RT, with IC50 values of 119 mu M, 100 mu M, 116 mu M, 236 mu M, and 170 mu M, respectively. Morelloflavone (7) also demonstrated significant antiviral activity against HIV-1 (strain LAV-1) in phytohemagglutinin-stimulated primary human peripheral blood mononuclear cells at an EC50 value of 6.9 mu M and a selectivity index value of approximately 10. The other biflavonoids were either weakly active, inactive, or not selective against HIV-1 in human lymphocytes. [References: 45]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel