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Long-Term Protection of Chimpanzees Against High-Dose Hiv-1 Challenge Induced By Immunization

  1. Author:
    Lubeck, M. D.
    Natuk, R.
    Myagkikh, M.
    Kalyan, N.
    Aldrich, K.
    Sinangil, F.
    Alipanah, S.
    Murthy, S. C. S.
    Chanda, P. K.
    Nigida, S. M.
    Markham, P. D.
    Zollapazner, S.
    Steimer, K.
    Wade, M.
    Reitz, M. S.
    Arthur, L. O.
    Mizutani, S.
    Davis, A.
    Hung, P. P.
    Gallo, R. C.
    Eichberg, J.
    Robertguroff, M.

  2. Author Address

    Lubeck MD WYETH LEDERLE VACCINES & PEDIAT POB 304 MARIETTA, PA 17547 USA WYETH AYERST RES RADNOR, PA 19087 USA NCI TUMOR CELL BIOL LAB NIH BETHESDA, MD 20892 USA CHIRON CORP EMERYVILLE, CA 94608 USA NCI FREDERICK CANC RES & DEV CTR PROGRAM RESOURCES INC FREDERICK, MD 21702 USA ADV BIOSCI LABS KENSINGTON, MD 20895 USA VET AFFAIRS MED CTR NEW YORK, NY 10010 USA
    1. Year: 1997
  2. Journal: Nature Medicine
    1. 3
    2. 6
    3. Pages: 651-658
  4. Type of Article: Article
  1. Abstract:

    A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1(MN)gp160 recombinants followed by boosting with HIV-1(SF2)gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved against a low-dose challenge with the SF2 strain of HIV-1 and a subsequent high-dose SF2 challenge administered 1 year later without an intervening boost. Notably, neutralizing antibody responses against both clinical and laboratory isolates developed in three chimpanzees and persisted until the time of high-dose challenge. The possibility that cytotoxic T-lymphocytes contribute to row-dose protection of a chimpanzee lacking neutralizing antibodies is suggested. Our results validate the live vector priming/subunit booster approach and should stimulate interest in assessing this combination vaccine approach in humans. [References: 42]

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