Skip NavigationSkip to Content
Return Return to Search Results

Dysregulation of T lymphocyte function in itchy mice: a role for itch in T(H)2 differentiation

  1. Author:
    Fang, D. Y.
    Elly, C.
    Gao, B. X.
    Fang, N.
    Altman, Y.
    Joazeiro, C.
    Hunter, T.
    Copeland, N.
    Jenkins, N.
    Liu, Y. C.

  2. Author Address

    La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA. La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA. Salk Inst Biol Studies, La Jolla, CA 92037 USA. NCI, Frederick, MD 21702 USA. Liu YC La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA.
    1. Year: 2002
  2. Journal: Nature Immunology
    1. 3
    2. 3
    3. Pages: 281-287
  4. Type of Article: Article
  1. Abstract:

    Itch is an E3 ubiquitin ligase that is disrupted in nonagouti- lethal or itchy mice. Itch deficiency leads to severe immune and inflammatory disorders and constant itching of the skin. Here we show that Itch(-/-) T cells show an activated phenotype and enhanced proliferation. Production of the type 2 T helper (T(H)2) cell cytokines interleukin 4 (IL-4) and IL-5 by Itch-/- T cells was augmented upon stimulation, and the T(H)2-dependent serum concentrations of immunoglobulin G1 (IgG1) and IgE in itchy mice were also increased. Molecularly, Itch associated with and induced ubiquitination of JunB, a transcription factor that is involved in T(H)2 differentiation. These results provide a molecular link between Itch deficiency and the aberrant activation of immune responses in itchy mice.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel