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The Complexity of Raf-1 Regulation

  1. Author:
    Morrison, D. K.
    Cutler, R. E.
  2. Author Address

    Morrison DK NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MOL BASIS CARCINOGENESIS LAB FREDERICK, MD 21702 USA
    1. Year: 1997
  1. Journal: Current Opinion in Cell Biology
    1. 9
    2. 2
    3. Pages: 174-179
  2. Type of Article: Article
  1. Abstract:

    The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms. [References: 62]

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