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gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

  1. Author:
    Fortini, M. E.

  2. Author Address

    NCI, Div Basic Sci, Bldg 560,Room 22-12,Ft Detrick, Frederick, MD 21702 USA NCI, Div Basic Sci, Frederick, MD 21702 USA Fortini ME NCI, Div Basic Sci, Bldg 560,Room 22-12,Ft Detrick, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Nature Reviews Molecular Cell Biology
    1. 3
    2. 9
    3. Pages: 673-684
  4. Type of Article: Review
  1. Abstract:

    Many cell-surface receptors transmit signals to the nucleus through complex protein cascades. By contrast, the Notch signalling pathway uses a relatively direct mechanism, in which the intracellular domain of the receptor is liberated by intramembrane cleavage and translocates to the nucleus. This critical cleavage is mediated by the gamma-secretase complex, and new findings reveal that this mechanism is used by various receptors, although many questions remain about the biochemical details.

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