Skip NavigationSkip to Content
Return Return to Search Results

Epigenetic control during lymphoid development and immune responses - Aberrant regulation, viruses, and cancer

  1. Author:
    Muegge, K.
    Young, H.
    Ruscetti, F.
    Mikovits, J.

  2. Author Address

    Mikovits J EpiGenX Pharmaceut Inc, 5385 Hollister Ave, Santa Barbara, CA 93111 USA
    1. Year: 2003
  2. Book Title: Epigenetics in Cancer Prevention: Early Detection and Risk Assessment
  3. Series Title: Annals of the New York Academy of Sciences
    1. 983
    2. Pages: 55-70
  5. Type of Work: Book Chapter
  1. Abstract:

    Methylation of cytosines controls a number of biologic processes such as imprinting and X chromosomal inactivation. DNA hypermethylation is closely associated with transcriptional silencing, while DNA hypomethylation is associated with transcriptional activation. Hypoacetylation of histones leads to compact chromatin with reduced accessibility to the transcriptional machinery. Methyl-CpG binding proteins can recruit corepressors and histone deacetylases; thus, the interplay between these epigenetic mechanisms regulates gene activation. Methylation has been implicated as an important mechanism during immune development, controlling VDJ recombination, lineage-specific expression of cell surface antigens, and transcriptional regulation of cytokine genes during immune responses. Aberrations in epigenetic machinery, either by genetic mutations or by somatic changes such as viral infections, are associated with early alterations in chronic diseases such as immunodeficiency and cancer.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel