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Peropsin, a Novel Visual Pigment-Like Protein Located in the Apical Microvilli of the Retinal Pigment Epithelium

  1. Author:
    Sun, H.
    Gilbert, D. J.
    Copeland, N. G.
    Jenkins, N. A.
    Nathans, J.

  2. Author Address

    Nathans J JOHNS HOPKINS UNIV SCH MED DEPT MOL BIOL & GENET 805 PCTB 725 N WOLFE ST BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV SCH MED DEPT MOL BIOL & GENET BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV SCH MED DEPT NEUROSCI BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV SCH MED DEPT OPHTHALMOL BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV SCH MED HOWARD HUGHES MED INST BALTIMORE, MD 21205 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MAMMALIAN GENET LAB FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 94
    2. 18
    3. Pages: 9893-9898
  4. Type of Article: Article
  1. Abstract:

    A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues, The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE), Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments, These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds. [References: 30]

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