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Gestation stage-specific oxidative deoxyribonucleic acid damage from sidestream smoke in pregnant rats and their fetuses

  1. Author:
    Maciag, A.
    Bialkowska, A.
    Espiritu, I.
    Powell, D.
    Alvord, W. G.
    Kasprzak, K. S.
    Anderson, L. M.
    Witschi, H. R.

  2. Author Address

    NCI, Lab Comparat Carcinogenesis, Bldg 538, Frederick, MD 21702 USA NCI, Lab Comparat Carcinogenesis, Frederick, MD 21702 USA Univ Calif Davis, Ctr Hlth & Environm, Davis, CA 95616 USA Data Management Serv Inc, Frederick, MD USA Anderson LM NCI, Lab Comparat Carcinogenesis, Bldg 538, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Archives of Environmental Health
    1. 58
    2. 4
    3. Pages: 238-244
  4. Type of Article: Article
  1. Abstract:

    Transplacental exposure to environmental tobacco smoke (ETS) is a possible cancer risk factor in offspring. The authors exposed pregnant Sprague-Dawley rats to a relevant dose of ETS (1 mg/m(3)) from gestation day 4 to days 16 or 21. They then assayed tissues for levels of 8-oxo-2'-deoxyguanosine (8-oxo- dG), a marker of oxidative deoxyribonucleic acid damage. ETS exposure ending on gestation day 16 resulted in statistically significant increases in 8-oxo-dG in maternal liver and kidney and in fetal kidney. On gestation day 21, there were significant 8-oxo-dG increases in fetal liver and brain. These gestational stage- and tissue-specific increases of 1.2- to 1.4-fold are similar to the putative relative increases in risk of human cancers related to ETS.

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