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Antitumor agents. 228. Five new agarofurans, reissantins A-E, and cytotoxic principles from Reissantia buchananiii

  1. Author:
    Chang, F. R.
    Hayashi, K.
    Chen, I. H.
    Liaw, C. C.
    Bastow, K. F.
    Nakanishi, Y.
    Nozaki, H.
    Cragg, G. A.
    Wu, Y. C.
    Lee, K. H.

  2. Author Address

    Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA Okayama Univ Sci, Fac Sci, Dept Biochem, Okayama 7000005, Japan Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan Lee KH Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
    1. Year: 2003
  2. Journal: Journal of Natural Products
    1. 66
    2. 11
    3. Pages: 1416-1420
  4. Type of Article: Article
  1. Abstract:

    Twenty-one compounds, including five new agarofuran sesquiterpenes, reissantins A-E (1-5), were isolated from Reissantia buchananii by means of bioassay-directed fractionation and their structures identified from spectral data. Reissantins A-C are the first reported simple agarofuran sesquiterpenes to contain a 5-carboxy-N-methyl-2-pyridone (CNMP) substituent, which has previously been found only in macroring agarofuran pyridine alkaloids. The major terpenoid components, celastrol (6) and its methyl ester derivative, pristimerin (7), were significantly active against nine cancer cell lines, including A549, MCF-7, HCT-8, KB, KB-VIN, U-87-MG, PC-3, 1A9, and PTX10 cell lines, with ED50 values ranging from 0.076 to 0.34 mug/mL.

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