Skip NavigationSkip to Content
Return Return to Search Results

Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms

  1. Author:
    Mai, V.
    Colbert, L. H.
    Berrigan, D.
    Perkins, S. N.
    Pfeiffer, R.
    Lavigne, J. A.
    Lanza, E.
    Haines, D. C.
    Schatzkin, A.
    Hursting, S. D.

  2. Author Address

    NCI, Off Prevent Oncol, Canc Prevent Fellowship Program, Div Canc Prevent, 6130 Execut Blvd, Bethesda, MD 20892 USA NCI, Off Prevent Oncol, Canc Prevent Fellowship Program, Div Canc Prevent, Bethesda, MD 20892 USA NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI, Lab Biosyst & Canc, Canc Res Ctr, Bethesda, MD 20892 USA NCI, Appl Res Branch, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA Ctr Canc Res, Canc Prevent Studies Branch, Bethesda, MD 20892 USA Sci Applicat Int Corp, Pathol Histotechnol Lab, Frederick, MD 21702 USA Hursting SD NCI, Off Prevent Oncol, Canc Prevent Fellowship Program, Div Canc Prevent, 6130 Execut Blvd, Bethesda, MD 20892 USA
    1. Year: 2003
  2. Journal: Cancer Research
    1. 63
    2. 8
    3. Pages: 1752-1755
  4. Type of Article: Article
  1. Abstract:

    We evaluated the effects of diet on intestinal tumorigenesis in male Apc(Min) mice by comparing AIN-76A diet fed ad libitum (CON); calorie intake restricted by 40% of the CON (CR); diet high in olive oil and supplemented with freeze-dried fruit and vegetable extracts (OFV); and diet high in total fat (HF). Compared with CON, the frequency of intestinal polyps was reduced by 57% by CR (P < 0.001) and by 33% OFV diet (P = 0.04). Both effective interventions reduced total body weight, lean mass, and fat mass and increased daily urinary corticosterone output, but only CR reduced serum insulin-like growth factor I and leptin. We conclude that dietary interventions can partially offset genetic susceptibility to intestinal carcinogenesis.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel