Skip NavigationSkip to Content
Return Return to Search Results

Human herpesvirus 8 infection within families in rural Tanzania

  1. Author:
    Mbulaiteye, S. M.
    Pfeiffer, R. M.
    Whitby, D.
    Brubaker, G. R.
    Shao, J.
    Biggar, R. J.

  2. Author Address

    6120 Execut Blvd,Execut Plaza S,Rm 8007,Mail Sto, Rockville, MD 20852 USA NCI, Div Can Epidemiol & Genet, Bethesda, MD 20892 USA Sci Applicat Int Corp, Viral Epidemiol Sect, AIDS Vaccine Program, Frederick, MD USA NCI, Frederick, MD 21701 USA Shirati Hosp, Shirati, Tanzania Kilimanjaro Christian Med Ctr, Moshi, Tanzania Mbulaiteye SM 6120 Execut Blvd,Execut Plaza S,Rm 8007,Mail Sto, Rockville, MD 20852 USA
    1. Year: 2003
  2. Journal: Journal of Infectious Diseases
    1. 187
    2. 11
    3. Pages: 1780-1785
  4. Type of Article: Article
  1. Abstract:

    Human herpesvirus 8 (HHV-8) infection is common in Africa. We examined the distribution of HHV-8 within families in rural Tanzania to determine routes of spread. HHV-8 infection was assessed by measuring antibody reactivity with a K8.1 (lytic- phase antigen) immunoassay. The prevalence increased from 3.7% (1/27) among infants to 58.1% (36/62) among children aged 3-4 years and 89.0% (65/73) among adults aged greater than or equal to45 years. Women with HHV-8-seropositive husbands had a 7-fold risk for infection (odds ratio [OR], 6.9; 95% confidence interval [CI], 1.9-25.3). HHV-8 seropositivity in children was associated with having at least 1 seropositive first-degree relative (OR, 14.7; 95% CI, 5.9-43.1), a seropositive mother (OR, 7.4; 95% CI, 3.2-16.8), a seropositive father (OR, 4.8; 95% CI, 2.3-10.1), or a seropositive next-older sibling (OR, 4.2; 95% CI, 1.9-9.4). Our data are consistent with the occurrence of HHV-8 transmission within families, from mothers and other relatives to children via nonsexual routes and between spouses via sexual routes.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel